interleukin-10

[Nature Communications] GUT-103, composed of 17 strains that synergistically provide protective and sustained engraftment in the IBD inflammatory environment, prevented and treated chronic immune-mediated colitis.

[Cell Death & Disease] Adropin in vitro reduced hydrogen peroxide-induced apoptosis in rat bone marrow MSCs and improved MSCs survival with increased phosphorylation of Akt and extracellular regulated protein kinases.

[Advanced Healthcare Materials] The capability of extracellular vesicles (EVs) was leveraged to be engineered via producer cell modification to investigate the therapeutic potential of EVs from mesenchymal stem/stromal cells transfected to overexpress long non‐coding RNA HOX transcript antisense RNA (HOTAIR).

[Cell Reports] Investigators report that long-term stress surprisingly abrogates both T helper 1 (TH1)- and TH2-type responses orchestrated by invariant natural killer T cells.

[Scientific Reports] MSCs cultivated on temperature-responsive culture dishes to a confluent 2D monolayer were harvested by temperature reduction from 37 to 20°C that induced a surface wettability transition from hydrophobic to hydrophilic.

[Science] Interleukin-10 (IL-10) variants with a range of IL-10 receptor β binding strengths uncovered substantial differences in response thresholds across immune cell populations, providing a means of manipulating IL-10 cell type selectivity.