intestinal cells

[Cell Reports] Scientists proposed that a high-fat diet enhanced intestinal stemness and tumorigenicity by engaging a peroxisome proliferator-activated receptor-fatty acid oxidation (PPAR-FAO) program.

[eLife] In addition to impacting stem cell proliferation during damage-induced intestinal regeneration, the role of RAL GTPases impacted on EGFR-dependent tumorigenic growth in the intestine and in human mammary epithelium.

[Cell Death & Differentiation] Scientists examined the function of the RNF20/RNF40/H2Bub1 axis in intestinal inflammation in inflammatory bowel disease (IBD) patients and mouse models. They analyzed underlying molecular pathways in isolated primary intestinal epithelial cells and confirmed their findings in IBD resection specimens.

[Cell Death & Disease] Researchers analyzed colonic tissue samples from patients with ulcerative colitis (UC) and constructed specific intestinal epithelial phenazine biosynthesis-like domain-containing protein (PBLD)-deficient mice to investigate the role of this protein in UC pathogenesis.

[Scientific Reports] Using human intestinal cell lines, scientists discovered that C. minuta demonstrated strong anti-inflammatory activity, resulting in reduced levels of proinflammatory IL-8 cytokines via the inhibition of the NF-κB signaling pathway.

[Journal of Biological Chemistry] Scientists examined the relationship of RAB11A to epithelial junctional complexes, YAP, and the associated consequences on colonic epithelial tissue repair.