islets

[American Journal of Chinese Medicine] Researchers investigated the role of puerarin in endoplasmic reticulum stress-associated apoptosis and explore its underlying mechanism in the mouse insulinoma cell line.

[Lancet Diabetes & Endocrinology] The authors discuss the potential regenerative capacity of the remaining islet cells and the utility of stem cell-derived β-like cells to restore β-cell function and describe tissue engineering approaches that might improve the engraftment, function, and survival of β-cell replacement therapies.

[Nature Communications] Using massively parallel reporter assays, scientists tested the cis-regulatory effects of single nucleotide polymorphisms associated with type 2 diabetes (T2D) and altered in vivo islet chromatin accessibility in MIN6 β cells under steady state and pathophysiologic endoplasmic reticulum stress conditions.

[Nature Communications] HLA-DQ8-HIP tetramer+ T cells from the peripheral blood of a T1D patient are characterized by repeated TRBV5 usage, which matched the TCR bias of CD4+ T cells reactive to the HIP peptide isolated from the pancreatic islets of a patient with T1D.

[Cell Reports] Scientists reported that pro-inflammatory β cell small extracellular vesicles induced β cell dysfunction, promoted a pro-inflammatory islet transcriptome, and enhanced recruitment of CD8+ T cells and macrophages.

[Nature Communications] Researchers showed that Tet2 regulated pathologic interactions between β cells and immune cells and controlled damaging inflammatory pathways.