T Cell Receptor Recognition of Hybrid Insulin Peptides Bound to HLA-DQ8

By
Justin.choi
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0
318
HLA-DQ8-HIP tetramer+ T cells from the peripheral blood of a T1D patient are characterized by repeated TRBV5 usage, which matched the TCR bias of CD4+ T cells reactive to the HIP peptide isolated from the pancreatic islets of a patient with T1D.
[Nature Communications]
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Tran, M. T., Faridi, P., Lim, J. J., Ting, Y. T., Onwukwe, G., Bhattacharjee, P., Jones, C. M., Tresoldi, E., Cameron, F. J., La Gruta, N. L., Purcell, A. W., Mannering, S. I., Rossjohn, J., & Reid, H. H. (2021). T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8. Nature Communications, 12(1), 5110. https://doi.org/10.1038/s41467-021-25404-x Cite
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