keratinocytes

[Leukemia] Investigators found that CD109 suppressed TGF-β signaling in hematopoietic stem progenitor cells (HSPCs), and increased the sensitivity of PIGA-mutated HSPCs to TGF-β, leading to the preferential commitment of erythroid progenitor cells to mature red blood cells in immune-mediated bone marrow failure.

[Nature Communications] Investigators discovered that proteoglycan Agrin was enriched within the early wound-microenvironment and was indispensable for efficient healing.

[Cell Death & Disease] The authors investigated a previously unrecognized role for ferroptosis in psoriasis, where ferroptosis was mediated by lipid peroxidation and iron overload. They found that ferrostatin-1 blocked inflammatory responses in vitro and in vivo, which reduced cytokine production.

[Biochemical and Biophysical Research Communications] Researchers reported that chlorogenic acid treatment induced production of procollagen type I in human dermal fibroblast, Hs68 cell lines.

[Cell Death & Disease] Researchers confirmed the downregulation of miR-193b-3p in psoriasis patients, psoriasis-like inflammatory cellular models, and an imiquimod-induced mouse model.

[Journal of Cellular and Molecular Medicine] Investigators explored the role of glycolysis inhibition by 2-Deoxy-D-glucose on regulating immune responses of oral lichen planus-derived T cells.