keratinocytes

[Stem Cells Translational Medicine] Scientists tested the efficacy of the MSC secretome in a physiologically relevant ex vivo equine skin biofilm explant model and explored the impact of the MSC secretome on the antimicrobial defense mechanisms of resident skin cells.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists showed that in atopic dermatitis, IL-4 and IL-13 stimulated the expression of 3β-hydroxysteroid dehydrogenase 1, a key rate-limiting enzyme in sex steroid hormone synthesis, predominantly expressed by sebaceous glands in human skin.

[Scientific Reports] Performing in situ hybridization and immunofluorescence analysis, researchers found that mouse Hmcn1 and Hmcn2 showed a complementary distribution throughout different tissues and developmental stages.

[Scientific Reports] Through in vitro experiments, scientists found that genistein reduced IL-17A and TNF-α induced MAPK, NF-κB, and PI3K activation in normal human epidermal keratinocytes.

[Stem Cell Research & Therapy] Scientists reported that both human amniotic stem cells and their conditional medium had a potent anti-hyperpigmentation in skin in vivo and in vitro.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists showed that mutant keratinocytes (KC) clone size was markedly reduced in the absence of RORγt+ lymphocytes or interleukin (IL)-22, both observed in association with expanding KC clones, and found that topical application of a RORγ/γt inhibitor during chronic ultraviolet (UV) exposure reduced local expression of IL-22 and IL-17A while markedly limiting mutant p53 KC clonal expansion.