keratinocytes

[Aging] To investigate the functions of exosomes derived from human umbilical cord MSC (hucMSC-ex) in a rat model of acute skin photodamage, immunofluorescence and immunohistochemical staining, quantitative real-time-polymerase chain reaction, western blot, and gene silencing assays were performed.

[Journal of Investigative Dermatology] Researchers investigated whether intracellular IL-33 is involved in IL-4/IL-13 function. In monolayer-culture and living skin equivalent, IL-4/IL-13 increased the expression of full-length IL-33 in the nucleus of keratinocytes by activating the MEK/ERK signaling pathway, which is necessary for the inhibition of differentiation markers filaggrin, loricrin, keratin1, and keratin 10.

[Advanced Healthcare Materials] The capability of extracellular vesicles (EVs) was leveraged to be engineered via producer cell modification to investigate the therapeutic potential of EVs from mesenchymal stem/stromal cells transfected to overexpress long non‐coding RNA HOX transcript antisense RNA (HOTAIR).

[Scientific Reports] Scientists investigated the interactions of derivatives of lumisterol (L3) and vitamin D3 (D3) with liver X receptors (LXRs)

[Proceedings of the National Academy of Sciences of the United States of America] Researchers detected a focal, canonical hypomethylation phenotype that revealed considerable overlap with hypomethylated regions found in Dnmt3a-deficient mouse skin.

[Cancer Letters] Patient-derived organoids (PDOs) from human tissue samples allow for unique and faithful in vitro modeling of esophageal cancers, and provide an exciting platform for investigation into personalized medicine and targeted treatment approaches