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Pulmonary Cell NewsResearchers investigated whether intracellular IL-33 is involved in IL-4/IL-13 function. In monolayer-culture and living skin equivalent, IL-4/IL-13 increased the expression of full-length IL-33 in the nucleus of keratinocytes by activating the MEK/ERK signaling pathway, which is necessary for the inhibition of differentiation markers filaggrin, loricrin, keratin1, and keratin 10.
[Journal of Investigative Dermatology]
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Dai, X., Utsunomiya, R., Shiraishi, K., Mori, H., Muto, J., Murakami, M., & Sayama, K. (2021). Nuclear IL-33 plays an important role in the suppression of filaggrin, loricrin, keratin 1, and keratin 10 by IL-4 and IL-13 in human keratinocytes. Journal of Investigative Dermatology, 0(0). https://doi.org/10.1016/j.jid.2021.04.002 Cite
