kidney cells

[Scientific Reports] Scientists hypothesized that key human PAX2-dependent kidney development genes are differentially expressed in nephron progenitor cells from induced pluripotent stem cells in patients with renal coloboma syndrome relative to healthy individuals.

[Scientific Reports] Scientists evaluated the effects of Lithocholic bile acid (LCA) on nephroblastoma. To test the effects of LCA, nephroblastoma cell line WT CLS1 was used.

[Science Advances] Scientists suggested that artificial cells were a versatile chassis for the in situ synthesis and on-demand release of chemical signals that elicited desired phenotypic changes of eukaryotic cells, including neuronal differentiation.

[Life Sciences] Scientists studied TTA-A2 and paclitaxel in lung adenocarcinoma cell line- A549, cancer cells and human embryonic kidney cell line- HEK 293, control cell, in their monolayer and spheroids forms for viability, proliferation, morphology change, migration, and invasion-after 48–96 hours of treatment.

[Stem Cell Research & Therapy] Researchers aimed to develop a novel kind of 3D organoids generated from urine-derived stem cells and to explore whether kidney-specific extracellular matrix could enable such organoids for renal function in vitro.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators found that human and mouse macrophages underwent a switch to glycolysis in response to IgG immune complex stimulation, mirroring macrophage metabolic changes in inflamed tissue in vivo. This metabolic reprogramming was required to generate a number of proinflammatory mediators, including IL-1β, and was dependent on mTOR and hypoxia-inducible factor-1α.