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leukocytes

Genetic Inhibition of RIPK3 Ameliorates Functional Outcome in Controlled Cortical Impact Independent of Necroptosis

[Cell Death & Disease] Researchers used a model of cerebral contusion and receptor interacting protein kinase 3 (RIPK3) and mixed lineage kinase like knockout (MLKL−/−) mice, and found evidence for activation of RIPK3 and MLKL and assembly of a RIPK1-RIPK3-MLKL necrosome complex in pericontusional brain tissue.

Forensic Significance of Intracardiac Heme Oxygenase-1 Expression in Acute Myocardial Ischemia

[Scientific Reports] The authors examined the immunohistochemical expression of heme oxygenase-1 in the heart samples to discuss their forensic significance to determine acute cardiac ischemia.

Human Umbilical Mesenchymal Stromal Cells Mixed with Hyaluronan Transplantation Decreased Cartilage Destruction in a Rabbit Osteoarthritis Model

[Stem Cells International] The authors evaluated the capability of human umbilical cord mesenchymal stromal cells mixed with hyaluronan to treat osteoarthritis in a rabbit model.

p32 Promotes Melanoma Progression and Metastasis by Targeting EMT Markers, Akt/PKB Pathway, and Tumor Microenvironment

[Cell Death & Disease] The authors identified the role of p32 in the malignancy of both murine and human melanoma and found that p32 knockdown led to reduced cell proliferation, migration, and invasion in murine and human melanoma cells.

Endothelial Cell Autophagy Keeps Neutrophil Trafficking under Control

[Autophagy] Researchers identified endothelial cell autophagy as a negative regulator of neutrophil diapedesis in acute physiological inflammation.

Arthritis Flares Mediated by Tissue-Resident Memory T Cells in the Joint

[Cell Reports] In three murine models, CD8+ cells bearing resident memory T cells markers remained in previously inflamed joints during remission.

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