lung cancer cells

[Cell Death & Disease] The authors found that the expression of REV1 was significantly upregulated in lung cancer tissues compared with matched adjacent tissues and was associated with poor prognosis.

[Nature Communications] By utilizing a ΔNp63-specific conditional knockout mouse model and xenograft models of lung adenocarcinoma and squamous cell carcinoma, scientists found that ∆Np63 promoted NSCLC by maintaining the lung stem cells necessary for lung cancer cell initiation and progression in quiescence.

[Journal of Experimental & Clinical Cancer Research] The authors reported that stimuli from the embryonic lung could modulate the malignant phenotype of lung cancer cells, control their growth capacity and activate their differentiation into myofibroblasts.

[European Journal of Pharmaceutical Sciences] Scientists evaluated in vitro drug release, in vitro cytotoxicity on A549 lung cancer cells, nebulization performance using next generation impactor, and the in vivo biodistribution behavior.

[Cell Death & Disease] Researchers identified neurokinin-1 as a significantly upregulated GPCR in the transcriptome and tissue array of human lung cancer samples, associated with advanced clinical stages and poor prognosis.

[Chemico-Biological interactions] Scientists synthesized a series of small molecule compounds with the potential to inhibit eIF4E. Among them, the compound EGPI-1 significantly inhibited the proliferation of a variety of lung cancer cells such as A549, NCI-H460, NCI-H1650 and 95D without inhibiting the proliferation of HUVEC cells.