lung cancer

[Experimental & Molecular Medicine] The authors reported that BIX01294 (BIX) induced apoptotic cell death in EGFR-mutant NSCLC cells but not in their wild-type counterparts. Treatment with BIX resulted in a significant reduction in the EGFR level and inhibition of EGFR signaling only in EGFR-mutant NSCLC cells, leading to apoptosis.

[npj Precision Oncology] Investigators utilized 343 longitudinal plasma DNA samples from 43 ALK alterations NSCLC patients receiving ALK-directed therapies to determine molecular progression based on matched panel-based targeted next-generation sequencing, and shallow whole-genome sequencing.

[Stem Cell Research & Therapy] Researchers identified lncRNAs that were dysregulated in human induced pluripotent stem cell-derived endothelial cells following 24 hours of electronic-cigarette aerosol extract treatment via microarray analysis.

[Oncogene] Researchers demonstrate that lung adenocarcinoma was suppressed in oncogenic KrasG12D-driven mouse models engineered for pS727-STAT3 deficiency.

[Cancer Cell International] Investigators explored the mechanisms and correlation between miR-29c and muscle wasting in lung cancer cachexia.

[Scientific Reports] Scientists used publicly available single-cell RNAseq data to investigate the impact and diversity of global methylation status on lung adenocarcinoma.