lymphocytes

[Signal Transduction and Targeted Therapy] Investigators provide a comprehensive snapshot of the various molecules involved in regulating T cell receptor signaling, covering both enzymes and adaptors, and discuss their role in human disease.

[Pediatric Research] Scientists evaluated the effect of hydroxyurea on immune profiles through a controlled prospective cohort study conducted in 30 children with sickle cell anemia and 30 healthy age-matched controls.

[Cell Reports] Scientists identified SARS-CoV-2 RNA-dependent RNA-polymerase as highly conserved likely due to its critical role in the virus life cycle.

[Clinical infectious Diseases] The authors investigated cellular immune responses up to five years after infection in a cohort of 59 Middle East respiratory syndrome survivors by performing ELISPOT assay and intracellular cytokine staining after stimulation of peripheral blood mononuclear cells with synthetic viral peptides.

[Cell Reports] Investigators performed in vivo and in vitro CRISPR screens to systematically identify genes influencing CD8 T cell expansion.

[Science Immunology] Mouse infant T cells showed increased sensitivity to low antigen doses, originating at the interface between T cells and antigen-bearing accessory cells—through actin-mediated mobilization of signaling molecules to the immune synapse.