lymphocytes

[Haematologica] The authors showed that, unlike normal B cells, diffuse large B cell lymphoma (DLBCL) cells express abundant levels of transducin b-like protein 1 and its overexpression correlates with poor clinical outcome regardless of DLBCL molecular subtype.

[Nature Communications] Investigators indicated that 5′-Azacitidine increased the immunogenicity of acute myeloid leukemia cells, enhancing recognition and elimination of malignant cells by highly efficient CTLA-4negative anti-CD123 chimeric antigen receptor (CAR) T cells.

[Blood Cancer Journal] To obtain a comprehensive picture of composite genetic driver events and clonal dynamics in subtypes of pediatric acute lymphoblastic leukemia, scientists analyzed tumor-normal whole genome sequencing and expression data from 361 newly diagnosed patients.

[Bone Marrow Transplantation] The authors evaluated long-term outcome in 40 patients with myelodysplastic syndrome or acute myeloid leukemia, transplanted from related or unrelated donors following conditioning with targeted busulfan, fludarabine, and thymoglobulin.

[Nature Communications] Scientists reported overexpression of human mature T cell proliferation 1 gene (MTCP1) restricted to the B cell compartment in mice produced a clonal CD5+/CD19+ leukemia recapitulating the major characteristics of human chronic lymphocytic leukemia.

[Cell Death Discovery] The abundance of myeloid-derived suppressor cells in the tumour microenvironment was associated with therapeutic efficacy and disease outcome. Scientists analyzed the changes in the immune contexture in response to the carbon ion treatment.