Tag results:
lymphocytes
Immunology of Infectious Disease News
Identification of a Kupffer Cell Subset Capable of Reverting the T Cell Dysfunction Induced by Hepatocellular Priming
[Immunity] Researchers used a mouse model of hepatitis B virus (HBV) infection, in which HBV-specific naive CD8+ T cells recognizing hepatocellular antigens were driven into a state of immune dysfunction, to identify a subset of Kupffer cells that cross-presents hepatocellular antigens upon interleukin-2 administration.
Human Immunology News
Cooperativity Mediated by Rationally Selected Combinations of Human Monoclonal Antibodies Targeting the Henipavirus Receptor Binding Protein
[Cell Reports] Scientists isolated a panel of human monoclonal antibodies from the B cells of an individual with prior exposure to equine Hendra virus vaccine, targeting distinct antigenic sites.
Human Immunology News
High-Grade Serous Ovarian Tumor Cells Modulate NK Cell Function to Create an Immune-Tolerant Microenvironment
[Cell Reports] Researchers applied mass cytometry and uncover decidual-like natural killer cell subpopulations in newly diagnosed high-grade serous carcinoma samples that correlated with both tumor and transitioning epithelial-mesenchymal cell abundance.
Human Immunology News
Targeting the Atf7ip-Setdb1 Complex Augments Antitumor Immunity by Boosting Tumor Immunogenicity
[Cancer Immunology Research] To identify epigenetic regulators of tumor antigen expression, scientists established a transplantable syngeneic tumor model of immune escape with silenced antigen expression and used this system as a platform for a CRISPR-Cas9 suppressor screen for genes encoding epigenetic modifiers.
Immune Regulation News
Dendritic Cell Functions in the Inductive and Effector Sites of Intestinal Immunity
[Mucosal Immunology] Investigators summarize recent findings related to intestinal dendritic cells in steady state and upon inflammation, with a special focus on their functional specializations, highly dependent on their microenvironment.
Immune Regulation News
Myeloid Cell-Based Delivery of IFN-γ Reprograms the Leukemia Microenvironment and Induces Anti-Tumoral Immune Responses
[EMBO Molecular Medicine] The authors employed gene transfer into hematopoietic stem and progenitor cells to selectively express anti-tumoral cytokines in tumor-infiltrating monocytes/macrophages.