lymphocytes

[Advanced Healthcare Materials] The construction of a 1,3-propanesultone-grafted zwitterionic dendrimer-entrapped gold nanoparticle platform chelated with Gd(III) for immune checkpoint modulation is reported.

[Cold Spring Harbor Perspectives in Biology] Nomenclature reflecting the mutually opposing nature of T-cell self-renewal and T-cell differentiation would help synchronize phenomena such as T-cell memory, protective immunity, and T-cell exhaustion with other regenerative paradigms, as well as offer new strategies to influence the intensity and duration of immunity.

[Journal of Clinical Investigation] Mechanistically, scientists demonstrated that NK cell degranulation is mediated by binding of the Fc segment of anti-RhD antibodies to CD16, the main Fcγ receptor expressed on NK cells.

[Nature Reviews Rheumatology] Some patients do not respond to TNF inhibitor treatment and rare occurrences of paradoxical disease exacerbation have been reported. These limitations on the clinical efficacy of TNF inhibitors can be explained by the differences between TNF receptor 1 (TNFR1) and TNFR2 signalling and by the diverse effects of TNF on multiple immune cells, including FOXP3+ regulatory T cells.

[Nature Cancer] Scientists investigated the mechanisms of selection in childhood B-cell precursor acute lymphoblastic leukemia during induction chemotherapy where maximal cytoreduction occurs.

[European Journal of Immunology] Researchers reported a direct comparison of E2- and P4-mediated effects on human CD4+ T cells, key cells in immune regulation. T cells were stimulated to obtain different levels of activation and exposed to a broad range of hormone concentrations.