Some patients do not respond to TNF inhibitor treatment and rare occurrences of paradoxical disease exacerbation have been reported. These limitations on the clinical efficacy of TNF inhibitors can be explained by the differences between TNF receptor 1 (TNFR1) and TNFR2 signalling and by the diverse effects of TNF on multiple immune cells, including FOXP3+ regulatory T cells.
[Nature Reviews Rheumatology]
6445218 9P9A3Z3P items 1 apa 0 default asc 1 164215 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/ %7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-8fc9f297873b5500b1141462f99407ba%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%229P9A3Z3P%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Salomon%22%2C%22parsedDate%22%3A%222021-07-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ESalomon%2C%20B.%20L.%20%282021%29.%20Insights%20into%20the%20biology%20and%20therapeutic%20implications%20of%20TNF%20and%20regulatory%20T%20cells.%20%3Ci%3ENature%20Reviews%20Rheumatology%3C%5C%2Fi%3E%2C%201%26%23x2013%3B18.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41584-021-00639-6%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41584-021-00639-6%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3D9P9A3Z3P%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Insights%20into%20the%20biology%20and%20therapeutic%20implications%20of%20TNF%20and%20regulatory%20T%20cells%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benoit%20L.%22%2C%22lastName%22%3A%22Salomon%22%7D%5D%2C%22abstractNote%22%3A%22Treatments%20that%20block%20tumour%20necrosis%20factor%20%28TNF%29%20have%20major%20beneficial%20effects%20in%20several%20autoimmune%20and%20rheumatic%20diseases%2C%20including%20rheumatoid%20arthritis.%20However%2C%20some%20patients%20do%20not%20respond%20to%20TNF%20inhibitor%20treatment%20and%20rare%20occurrences%20of%20paradoxical%20disease%20exacerbation%20have%20been%20reported.%20These%20limitations%20on%20the%20clinical%20efficacy%20of%20TNF%20inhibitors%20can%20be%20explained%20by%20the%20differences%20between%20TNF%20receptor%201%20%28TNFR1%29%20and%20TNFR2%20signalling%20and%20by%20the%20diverse%20effects%20of%20TNF%20on%20multiple%20immune%20cells%2C%20including%20FOXP3%2B%20regulatory%20T%20cells.%20This%20basic%20knowledge%20sheds%20light%20on%20the%20consequences%20of%20TNF%20inhibitor%20therapies%20on%20regulatory%20T%20cells%20in%20treated%20patients%20and%20on%20the%20limitations%20of%20such%20treatment%20in%20the%20control%20of%20diseases%20with%20an%20autoimmune%20component.%20Accordingly%2C%20the%20next%20generation%20of%20drugs%20targeting%20TNF%20is%20likely%20to%20be%20based%20on%20agents%20that%20selectively%20block%20the%20binding%20of%20TNF%20to%20TNFR1%20and%20on%20TNFR2%20agonists.%20These%20approaches%20could%20improve%20the%20treatment%20of%20rheumatic%20diseases%20in%20the%20future.%22%2C%22date%22%3A%222021-07-05%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41584-021-00639-6%22%2C%22ISSN%22%3A%221759-4804%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41584-021-00639-6%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-07-05T18%3A01%3A03Z%22%7D%7D%5D%7DSalomon, B. L. (2021). Insights into the biology and therapeutic implications of TNF and regulatory T cells.
Nature Reviews Rheumatology, 1–18.
https://doi.org/10.1038/s41584-021-00639-6 Cite