Tag results:
lymphocytes
ESC & iPSC News
Engineering the Next-Generation of CAR T-Cells with CRISPR-Cas9 Gene Editing
[Molecular Cancer] The authors evaluate several of the ongoing and future directions of combining next-generation CRISPR-Cas9 gene editing with synthetic biology to optimize CAR T-cell therapy for future clinical trials toward the establishment of a new cancer treatment paradigm.
Cell Therapy News
GLA/DRST Real-World Outcome Analysis of CAR-T Cell Therapies for Large B Cell Lymphoma in Germany
[Blood] The authors reported the first German real-world data on standard-of-care CAR-T cell therapies with the aim to explore risk factors associated with outcome.
Immunology of Infectious Disease News
Pandemic Influenza a (H1N1) Virus Causes Abortive Infection of Primary Human T Cells
[Emerging Microbes & Infections] Different T cell subpopulations have distinct characterizations and functions, and scientists revealed the high heterogeneity of susceptibility to viral infection and biological responses such as apoptosis in various CD4+ T and CD8+ T cell subsets through single-cell transcriptome analyses.
Human Immunology News
Tim-3 Mediates T Cell Trogocytosis to Limit Antitumor Immunity
[Journal of Clinical Investigation] Scientists showed that human PD-1+Tim-3+ CD8+ tumor-infiltrating lymphocytes upregulated phosphatidylserine, a receptor for Tim-3, and acquire cell surface myeloid markers from antigen presenting cells through transfer of membrane fragments called trogocytosis.
Mesenchymal Cell News
Human Umbilical Cord-Derived Mesenchymal Stem Cells Alleviate Insulin Resistance in Diet-Induced Obese Mice via an Interaction with Splenocytes
[Stem Cell Research & Therapy] Human umbilical cord-derived MSCs infusions improved systemic metabolic homeostasis and alleviated insulin resistance in epididymal adipose tissue but elicited no change in weight.
Hematopoiesis News
Wugen Announces First Patient Dosed in Phase I/II Trial of WU-CART-007 for the Treatment of Patients with R/R T-ALL/LBL
[Wugen, Inc.] Wugen, Inc. announced that the first patient has been dosed in a Phase I/II trial of WU-CART-007 for the treatment of relapsed or refractory T cell acute lymphoblastic leukemia (T-ALL)/lymphoblastic lymphoma.