Development of an Artificial Antibody Specific for HLA/Peptide Complex Derived from Cancer Stem-Like Cell/Cancer-Initiating Cell Antigen DNAJB8

Investigators developed a therapeutic single-chain variable-fragment antibody that recognises the cancer stem-like cell/cancer-initiating cell antigen, DNAJB8.
[British Journal of Cancer]
Abstract
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Cytovia Therapeutics Acquires Worldwide Rights to CytoImmune Therapeutics’ First-In-Class EGFR Dual-Targeting CAR for NK Cell Treatment of Glioblastoma & Other Solid Tumors

Cytovia Therapeutics, Inc announced that it has acquired worldwide rights from CytoImmune Therapeutics for its novel EGFR dual-targeting CAR to be used for NK cell therapy.
[Cytovia Therapeutics, Inc. (GlobeNewswire, Inc.)]
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In Vivo Gene Therapy for Canine SCID-X1 Using Cocal-Pseudotyped Lentiviral Vector

Scientists developed an in vivo gene therapy approach to treat canine X-linked severe combined immunodeficiency after hematopoietic stem and progenitor cell mobilization and systemic delivery of the therapeutic vector.
[Human Gene Therapy]
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Targeting HIV Env Immunogens to B Cell Follicles in Nonhuman Primates through Immune Complex or Protein Nanoparticle Formulations

Investigators demonstrated two strategies to concentrate HIV envelope immunogens in follicles, via the formation of immune complexes or by employing self-assembling protein nanoparticles for multivalent display of envelope antigens.
[NPJ Vaccines]
Martin, J. T., Cottrell, C. A., Antanasijevic, A., Carnathan, D. G., Cossette, B. J., Enemuo, C. A., Gebru, E. H., Choe, Y., Viviano, F., Fischinger, S., Tokatlian, T., Cirelli, K. M., Ueda, G., Copps, J., Schiffner, T., Menis, S., Alter, G., Schief, W. R., Crotty, S., … Irvine, D. J. (2020). Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations. Npj Vaccines, 5(1), 1–15. https://doi.org/10.1038/s41541-020-00223-1 Cite
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Selective and Cross-Reactive SARS-CoV-2 T Cell Epitopes in Unexposed Humans

Using human blood samples derived before the SARS-CoV-2 virus was discovered in 2019, the authors mapped 142 T cell epitopes across the SARS-CoV-2 genome to facilitate precise interrogation of the SARS-CoV-2-specific CD4+ T cell repertoire.
[Science]
Mateus, J., Grifoni, A., Tarke, A., Sidney, J., Ramirez, S. I., Dan, J. M., Burger, Z. C., Rawlings, S. A., Smith, D. M., Phillips, E., Mallal, S., Lammers, M., Rubiro, P., Quiambao, L., Sutherland, A., Yu, E. D., Antunes, R. da S., Greenbaum, J., Frazier, A., … Weiskopf, D. (2020). Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans. Science. https://doi.org/10.1126/science.abd3871 Cite
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CD8+ T Cells Are Crucial for Humoral Immunity Establishment by SA14-14-2 Live Attenuated Japanese Encephalitis Vaccine in Mice

In lethal virus challenge, investigators showed that CD4+ T‐cells alone, but not CD8+ T‐cells, were sufficient to confer vaccine‐mediated protection.
[European Journal of Immunology]
Kalia, A., Agrawal, M., & Gupta, N. (n.d.). CD8+ T cells are crucial for humoral immunity establishment by SA14-14-2 live attenuated Japanese encephalitis vaccine in mice. European Journal of Immunology, n/a(n/a). https://doi.org/10.1002/eji.202048745 Cite
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Marginal Zone Formation Requires ACKR3 Expression on B Cells

The authors showed that expression of atypical chemokine receptor 3 defined two equal-sized populations of mouse marginal B cells
[Cell Reports]
Radice, E., Ameti, R., Melgrati, S., Foglierini, M., Antonello, P., Stahl, R. A. K., Thelen, S., Jarrossay, D., & Thelen, M. (2020). Marginal Zone Formation Requires ACKR3 Expression on B Cells. Cell Reports, 32(5). https://doi.org/10.1016/j.celrep.2020.107951 Cite
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Mucosal or Systemic Microbiota Exposures Shape the B Cell Repertoire

Microbial exposures at the intestinal mucosa generated oligoclonal responses that differed from those of germ-free mice, and from the diverse repertoire that was generated after intravenous systemic exposure to microbiota.
[Nature]
Li, H., Limenitakis, J. P., Greiff, V., Yilmaz, B., Schären, O., Urbaniak, C., Zünd, M., Lawson, M. A. E., Young, I. D., Rupp, S., Heikenwälder, M., McCoy, K. D., Hapfelmeier, S., Ganal-Vonarburg, S. C., & Macpherson, A. J. (2020). Mucosal or systemic microbiota exposures shape the B cell repertoire. Nature, 1–5. https://doi.org/10.1038/s41586-020-2564-6 Cite
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Infection during the First Year in Patients Treated with CD19 CAR T Cells for Diffuse Large B Cell Lymphoma

The authors analyzed 60 patients with diffuse large B cell lymphoma treated with FDA-approved CD19 chimeric antigen receptor (CAR) T cells and report the incidence, risk factors, and management of infections during the first year after treatment.
[Blood Cancer Journal]
Wudhikarn, K., Palomba, M. L., Pennisi, M., Garcia-Recio, M., Flynn, J. R., Devlin, S. M., Afuye, A., Silverberg, M. L., Maloy, M. A., Shah, G. L., Scordo, M., Dahi, P. B., Sauter, C. S., Batlevi, C. L., Santomasso, B. D., Mead, E., Seo, S. K., & Perales, M.-A. (2020). Infection during the first year in patients treated with CD19 CAR T cells for diffuse large B cell lymphoma. Blood Cancer Journal, 10(8), 1–11. https://doi.org/10.1038/s41408-020-00346-7 Cite
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Treatment of Mice with S4B6 IL-2 Complex Prevents Lethal Toxoplasmosis via IL-12- and IL-18-Dependent Interferon-Gamma Production by Non-CD4 Immune Cells

Scientists investigated the in vivo regulation of IFN-γ production by CD8+ T cells, DN T cells and NK cells in response to acute Toxoplasma gondii infection.
[Scientific Reports]
Kupz, A., Pai, S., Giacomin, P. R., Whan, J. A., Walker, R. A., Hammoudi, P.-M., Smith, N. C., & Miller, C. M. (2020). Treatment of mice with S4B6 IL-2 complex prevents lethal toxoplasmosis via IL-12- and IL-18-dependent interferon-gamma production by non-CD4 immune cells. Scientific Reports, 10(1), 13115. https://doi.org/10.1038/s41598-020-70102-1 Cite
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In Situ Neutrophil Efferocytosis Shapes T Cell Immunity to Influenza Infection

Newly infiltrated inflammatory monocytes became a chief pool of phagocytes and played a key role in the clearance of highly motile apoptotic neutrophils during the resolution phase.
[Nature Immunology]
Lim, K., Kim, T., Trzeciak, A., Amitrano, A. M., Reilly, E. C., Prizant, H., Fowell, D. J., Topham, D. J., & Kim, M. (2020). In situ neutrophil efferocytosis shapes T cell immunity to influenza infection. Nature Immunology, 1–12. https://doi.org/10.1038/s41590-020-0746-x Cite
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