lymphoid cells

[Molecular Therapy-Nucleic Acids] A type of smart exosomes was developed, in which the exosome surface was functionally engineered with CD62L and OX40L by forced expression of the genes in the donor cells.

[Journal of Nanobiotechnology] Scientists developed a novel nanocomposite, polyethyleneimine-modified dendritic mesoporous silica nanoparticles loaded with microRNA-125a to synergistically enhance immune response and immunosuppression reversion, ultimately generating a tumoricidal environment.

[Cytokine] The authors investigated supportive therapy potential of acidophilus milk and propolis extract in the mouse xenograft breast cancer model.

[American Journal of Transplantation] Researchers performed full transcriptomic RNA sequencing and qPCR to evaluate the effects of mevalonate on the immunoregulatory phenotype of endothelial cells.

[BMC Cancer] The anti-cancer activities of BD0801 and its potential synergistic anti-tumor effects when combined with different immunotherapies were assessed by using in vitro assays and in vivo tumor models.

[Nature Immunology] Intestinal epithelial cell (IEC) damage by T cells contributes to graft-versus-host disease, inflammatory bowel disease and immune checkpoint blockade-mediated colitis. The relevance of IEC-intrinsic succinate dehydrogenase A in mediating disease severity was confirmed by complementary chemical and genetic experimental approaches and validated in human clinical samples.