lymphoid cells

[Blood Advances] Researchers conducted a Phase II study to test the activity of bortezomib and rituximab in combination with a pediatric-inspired regimen during induction therapy in newly diagnosed adolescents and adults with CD20-positive, Philadelphia (Ph)-negative precursor B-cell acute lymphoblastic leukemia.

[Leukemia] The average survival time was shorter in patients with JAK/STAT and PHF6 comutation than that in other patients, suggesting a potential role of PHF6 in leukemia progression.

[Immunity] By sensing IL-2 and cross-presenting hepatocellular antigens, a subset of kupffer cells overcame the tolerogenic potential of the hepatic microenvironment, suggesting new strategies for boosting hepatic T cell immunity.

[Cell Reports] Scientists reported the development of an improved system for monitoring HIV-1 fate at single-cell and population levels and showed the diverse applications of this system to study specific aspects of HIV-1 fate in different cell types and under different environments.

[Immunity] Researchers used a mouse model of hepatitis B virus (HBV) infection, in which HBV-specific naive CD8+ T cells recognizing hepatocellular antigens were driven into a state of immune dysfunction, to identify a subset of Kupffer cells that cross-presents hepatocellular antigens upon interleukin-2 administration.

[Cell Reports] Scientists isolated a panel of human monoclonal antibodies from the B cells of an individual with prior exposure to equine Hendra virus vaccine, targeting distinct antigenic sites.