lymphoid cells

[Pharmaceutical Biology] Human hepatic carcinoma cell lines were treated with different concentrations of myristicin for 24, 48 and 72 hours. Then tetrazolium assay, flow cytometer analysis and transwell assay were performed to determine cell proliferation, apoptosis and migration/invasion, respectively.

[Current Opinion in Biotechnology] Scientists offer a survey of recent biotechnological advances supporting enhanced and expedited biomanufacturing workflows for autologous and allogeneic cell therapies, ranging from novel genetic engineering techniques and cell sorting platforms to stem cells and tumor organoid models.

[Journal of Immunology] The authors discovered that the expression of P2Y6 was decreased upon the activation of the NK cells. In the P2Y6-deficient mice, scientists found that the deficiency of P2Y6 promoted the development of the NK precursor cells into immature NK and mature NK cells.

[Immunology] The authors found increased mouse IL-33 expression in CD8+ T cells following cell activation via anti-CD3/CD28 stimulation in vitro or Lymphocytic choriomeningitis virus (LCMV) infection in vivo.

[Nature Communications] HLA-DQ8-HIP tetramer+ T cells from the peripheral blood of a T1D patient are characterized by repeated TRBV5 usage, which matched the TCR bias of CD4+ T cells reactive to the HIP peptide isolated from the pancreatic islets of a patient with T1D.

[Journal of Experimental Medicine] The authors screened related Löfgren’s syndrome-specific TCRs for antigen specificity and identified a peptide derived from NAD-dependent histone deacetylase hst4 of Aspergillus nidulans that stimulated these CD4+ T cells in an HLA-DR3–restricted manner.