lymphoid cells

[Cell Reports] Scientists expanded SARS-CoV-2 T cells from the peripheral blood of COVID-19-recovered donors and non-exposed controls using different culture conditions.

[Scientific Reports] Researchers analyzed the expression of GADD45a and GADD45b in the skin, dendritic cells and circulating T cells in a cohort of psoriasis patients and their regulation by inflammatory signals.

[American Journal of Physiology-Gastrointestinal and Liver Physiology] Direct exposure of colonic epithelial organoids to dextran sulfate sodium, oxazolone, or TNBS resulted in increased apoptosis and loss of Lgr5+ cells. Targeted ablation of Lgr5+ cells resulted in severe exacerbation of chronic, antibody-induced IL-10-deficient colitis, but had only modest effects in TNBS-induced colitis.

[Nature Communications] The authors provided evidence that the SUMO protease SENP1 promoted T cell memory development via Sirt3 deSUMOylation. SENP1-Sirt3 signaling augmented the deacetylase activity of Sirt3, promoting both OXPHOS and mitochondrial fusion.

[Cancer Research] Investigators showed that inhibition of the hyperactive mevalonate (MVA) metabolic pathway in tumor cells elicited type 1 classical dendritic cells-mediated tumor recognition and antigen cross-presentation for antitumor immunity.

[Genes & Development] At the earliest stages of T cell development, cells with random chromosome gains and/or losses were selected against, but chromosomal instability eventually resulted in the expansion of progenitors with clonal chromosomal imbalances.