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Pulmonary Cell NewsAt the earliest stages of T cell development, cells with random chromosome gains and/or losses were selected against, but chromosomal instability eventually resulted in the expansion of progenitors with clonal chromosomal imbalances.
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Trakala, M., Aggarwal, M., Sniffen, C., Zasadil, L., Carroll, A., Ma, D., Su, X. A., Wangsa, D., Meyer, A., Sieben, C. J., Zhong, J., Hsu, P., Paradis, G., Ried, T., Holland, A., Deursen, J. V., & Amon, A. (2021). Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis. Genes & Development. https://doi.org/10.1101/gad.348341.121 Cite
