lymphoid cells

[npj Parkinsons Disease] Using two chimeric mouse models, scientists demonstrated that the replacement of mutant LRRK2 with wild-type formed of the protein in T- and B-lymphocytes diminished LPS-mediated inflammation and rescued the substantia nigra pars compacta dopamine neuron loss in the mutant LRRK2 brain.

[GeroScience] Effector T helper 1 genes were highly upregulated on aged Tregs, including the master regulator Tbx21.

[Journal of Photochemistry and Photobiology B-Biology] Researchers found that blue light-induced oxidative stress triggered the endoplasmic reticulum stress-C/EBP homologous protein signal and affected the protein levels of B-cell lymphoma-2 (Bcl-2) and Bcl2-associated X, thereby promoting apoptosis.

[Cell Metabolism] Scientists developed a dead-guide RNA-based CRISPR activation screen in primary CD8+ T cells and identified gain-of-function targets for CAR-T engineering.

[Nature Medicine] Researchers investigated the role of the intestinal microbiome onvarious outcomes in a multicenter study of patients with B cell lymphoma and leukemia.

[Cell Reports] Scientists reported that tumor-derived Jagged1 is a key regulator of the tumor immune microenvironment. Jagged1 promoted tumorigenesis in multiple spontaneous mammary tumor models.