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lymphoid cells

Phosphoantigen-Stimulated γδ T Cells Suppress Natural Killer Cell-Responses to Missing-Self

[Cancer Immunology Research] Scientists studied the consequences of pAg-stimulated γδ T cell interactions with Natural Killer cells and CD8+ T cells, major innate and adaptive effectors, respectively.

The Link between Circulating Follicular Helper T Cells and Autoimmunity

[Nature Reviews Immunology] The author discuss the increase in circulating Follicular helper T cells seen in autoimmune settings and explore potential explanations for this phenomenon.

Mild SARS-CoV-2 Infection in Rhesus Macaques Is Associated with Viral Control Prior to Antigen-Specific T Cell Responses in Tissues

[Science Immunology] The authors used rhesus macaques to model protective primary immune responses in tissues during mild COVID-19.

Harpoon Therapeutics Granted Orphan Drug Designation for HPN328 for Treatment of Small Cell Lung Cancer

[Harpoon Therapeutics, Inc.] Harpoon Therapeutics, Inc. announced that the US FDA has granted Orphan Drug Designation for HPN328, a delta like ligand 3- targeting TriTAC®, for the treatment of SCLC.

Bordetella pertussis-Infected Innate Immune Cells Drive the Anti-pertussis Response of Human Airway Epithelium

[Scientific Reports] Researchers investigated the epithelial cell response to B. pertussis infection in primary human airway epithelium differentiated at air–liquid interface.

Doxorubicin Induces Cardiotoxicity in a Pluripotent Stem Cell Model of Aggressive B Cell Lymphoma Cancer Patients

[Basic Research in Cardiology] Researchers established an in vitro iPSC model of anthracycline-induced cardiotoxicity (ACT) from patients with an aggressive form of B-cell lymphoma and examined whether doxorubicin-treated ACT-iPSC cardiomyocytes could recapitulate the clinical features exhibited by patients.

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