lymphoid cells

[PLoS Computational Biology] Researchers applied IQCELL to single cell RNA-seq datasets from early mouse T cell and red blood cell development, and showed that the platform could infer overall over 74% of causal gene interactions previously reported from decades of research.

[Cell Reports] Investigators showed that creatine supported cell-intrinsic CD8+ T cell homeostasis. They identified creatine kinase B as the creatine kinase isoenzyme that supported these T cell properties.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers enrolled cases of pandemic chilblains in a study and performed detailed immune profiling of antibody and T cell responses.

[Cancer Cell] Mechanistically, IFNγ stimulated ACSL4 and altered tumor cell lipid pattern, thereby increasing incorporations of arachidonic acid into C16 and C18 acyl chain-containing phospholipids.

[Biomedicine & Pharmacotherapy] Investigators demonstrated that dominant negative TGF-β receptor type II specifically targeting T cells decreased tumor load in tumor-bearing mice.

[Cell Reports] Scientists reported that high-level mitochondrial respiration and constitutive low-level glycolysis supported liver sinusoidal endothelial cells scavenger and sentinel functions