Phase Ib Study of the BET Protein Inhibitor RO6870810 with Venetoclax and Rituximab in Patients with Diffuse Large B Cell Lymphoma

Researchers reported results of a phase Ib dose-escalation study of the novel, subcutaneous BET inhibitor RO6870810 combined with the BCL-2 inhibitor venetoclax, and rituximab, in recurrent/refractory diffuse large B cell lymphoma.
[Blood Advances]
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Castleman Disease

VEGF is a potent angiogenic factor that may have a role in the pathogenesis of the Kaposi sarcoma herpesvirus (KSHV)-negative idiopathic form of multicentric Castelman disease (MCD) and KSHV-MCD, as endothelial cell and blood vessel proliferation is an important component of MCD.
[Nature Reviews Disease Primers]
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TAS-116 (Pimitespib), an HSP90 Inhibitor, Exhibits Efficacy in Preclinical Models of Adult T Cell Leukemia

The authors investigated the anti-adult T cell leukemia/lymphoma effects of a novel oral HSP90 inhibitor TAS-116 and the mechanisms involved in ex vivo and in vivo preclinical models.
[Cancer Science]
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MicroRNA-155-5p Initiates Childhood Acute Lymphoblastic Leukemia by Regulating the IRF4/CDK6/CBL Axis

Scientists explored putative mechanisms of microRNA-155-5p involvement in childhood acute lymphoblastic leukemia via interactions with casitas B-lineage lymphoma (CBL), interferon regulatory factor 4 (IRF4), and cyclin-dependent kinase 6 (CDK6).
[Laboratory Investigation]
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Oncostatin M Can Sensitize Sensory Neurons in Inflammatory Pruritus

Researchers found that the cytokine oncostatin M was highly up-regulated in psoriasis, atopic dermatitis, and cutaneous T cell lymphoma, diseases associated with chronic itch.
[Science Translational Medicine]
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Cardiovascular Events in Patients Treated with Chimeric Antigen Receptor T-cell Therapy for Aggressive B-cell Lymphoma

The authors retrospectively reviewed the characteristics and outcomes of adult patients with relapsed/refractory large B-cell lymphoma treated with Standard of care axicabtagene ciloleucel or tisagenlecleucel .
[Haematologica]
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Transducin β-Like Protein 1 Controls Multiple Oncogenic Networks in Diffuse Large B Cell Lymphoma

The authors showed that, unlike normal B cells, diffuse large B cell lymphoma (DLBCL) cells express abundant levels of transducin b-like protein 1 and its overexpression correlates with poor clinical outcome regardless of DLBCL molecular subtype.
[Haematologica]
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Treatment Strategies for a Rapidly Evolving Landscape in Chronic Lymphocytic Leukemia Management

Scientists address treatment duration and sequence considerations and discuss current targeted treatment dilemmas of chronic lymphocytic leukemia, where they review B cell lymphoma 2 inhibitors and Bruton’s tyrosine kinase in a fixed duration and continuous treatment manner.
[Hematological Oncology]
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Quantification of Cell-Free DNA for the Analysis of CD19-CAR-T Cells during Lymphoma Treatment

Cell-free DNA isolated from 74 blood samples of 12 patients during lymphoma treatment with the anti-CD19 CAR-T cell product axicabtagene ciloleucel were analyzed.
[Molecular Therapy-Methods & Clinical Development]
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Muscle-Specific Programmed Cell Death 5 Deletion Attenuates Cardiac Aging

Researchers revealed that programmed cell death 5 (Pdcd5) deficiency attenuated cardiac aging by reducing cellular senescence and apoptosis, and increasing Parkin-mediated mitophagy, likely through p53.
[International Journal of Cardiology]
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Moracin D Induces Apoptosis in Prostate Cancer Cells via Activation of PPAR Gamma/PKC Delta and Inhibition of PKC Alpha

Researchers explored the apoptotic mechanism of Moracin D in prostate cancer cells in association with peroxisome proliferator-activated receptor gamma (PPAR-γ)-related signaling involved in lipid metabolism.
[Phytotherapy Research]
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