GSK3 Inhibition Circumvents and Overcomes Acquired Lorlatinib Resistance in ALK-Rearranged Non-Small-Cell Lung Cancer

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Investigators established lorlatinib intermediate resistant cells from a patient-derived cell model. Glycogen synthase kinase 3 (GSK3) inhibitions significantly suppressed lorlatinib intermediate resistant cell growth.
[npj Precision Oncology]
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