Investigators used single-cell transcriptomics to profile 32,000 synovial tissue macrophages and identified phenotypic changes in patients with early/active rheumatoid arthritis (RA), treatment-refractory/active RA and RA in sustained remission.
[Nature Medicine]
Alivernini, S., MacDonald, L., Elmesmari, A., Finlay, S., Tolusso, B., Gigante, M. R., … Kurowska-Stolarska, M. (2020). Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis. Nature Medicine, 1–12. https://doi.org/10.1038/s41591-020-0939-8 Cite
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