macrophages

[Stem Cell Research & Therapy] Scientists summarize on the recent findings concerning the application of MSCs and their derivative exosome to support wound healing and skin regeneration, with special focus on last decade in vivo reports.

[Nature Communications] Scientists generated a comprehensive prostate cancer transcriptome atlas that described the roadmap to tumor progression in a qualitative and quantitative manner. Using patient-derived xenograft models, they functionally validated their observations and add single-cell resolution.

[Science Advances] Investigators showed that collagen deposition in response to the implantation of human split-thickness skin grafts containing live cells recapitulated normal skin architecture, whereas human acellular dermal matrix grafts led to a fibrotic collagen deposition.

[Cell Death & Disease] Scientists found that inhibition of monocyte-derived macrophages (MoMFs) SYK impaired the expression of CXCL1, reduced the recruitment of inflammatory cells, and promoted the phenotype cross-dress process of pro-resolution MoMFs, thereby remodeling the chronic inflammatory environment of the fibrotic liver.

[Experimental & Molecular Medicine] Researchers identified and functionally validated a long noncoding RNAs using human atherosclerotic plaques. Human aortic samples were obtained from patients who underwent aortic surgery, and tissues were classified according to atherosclerotic plaques.

[Human Immunology] The authors reviewed the molecular mechanisms and the role of immune cells and responses involved in pulmonary hypertension development.