macrophages

[Cellular Immunology] Researchers examined tumor-infiltrating lymphocytes in colorectal cancer expressing different levels of SIRT1.

[Cardiovascular Research] NOX1 mediated endothelial activation and contributed to myocardial inflammation and remodeling in metabolic disease in mice. Given its high expression in monocytes of humans with diastolic dysfunction (DD), NOX1 may represent a potential target to mitigate heart disease associated with DD.

[Cell Reports] Analysis of RNA sequencing data, including publicly available datasets, indicated that macrophage fragmentation was a general phenomenon that confounded bulk and single-cell analysis of disaggregated hematopoietic tissues.

[Cellular & Molecular Immunology] Increased Metrnβ effectively blocked the development of airway hyperreactivity and decreased inflammatory cell airway infiltration and type 2 cytokine production, which was associated with downregulated dendritic-mediated adaptive immune responses.

[NPJ Regenerative Medicine] To establish a well-defined 3D cell culture model to mimic the tissue repair process, researchers utilized THP-1 human monocytic cells and a 3D collagen matrix as a biomimetic tissue model.

[Trends in Immunology] Investigators hypothesize that macrophages produce catestatin in an inflammation-dependent manner and thereby might self-regulate inflammation in an autocrine fashion.