macrophages

[Clinical Cancer Research] Old and young mouse brains, metastatic and naïve, were analyzed by flow cytometry. Immune populations were depleted using antibodies or a colony stimulating factor-1 receptor (CSF-1R) inhibitor, and brain metastasis assays were conducted.

[Scientific Reports] Researchers described a study of a novel EMM composition comprising five amino acids and an amino acid derivative (Leucine, Isoleucine, Valine, Arginine, Glutamine, and N-acetylcysteine [LIVRQNac]) and its systematic evaluation across multiple NASH-relevant primary human cell model systems, including hepatocytes, macrophages, and stellate cells.

[Blood] Researchers reveal oncogene-induced, maladaptive induction of trained immunity in the pathogenesis of a human inflammatory myeloid neoplasm, Erdheim-Chester disease, characterized by the BRAFV600E oncogenic mutation in monocyte/macrophages and excess cytokine production.

[Cancer Cell] Scientists dissected glioblastoma-to-microenvironment interactions by single-cell RNA sequencing analysis of human tumors and model systems, combined with functional experiments.

[Science Advances] The authors reported the fine surface editing of MSC-EXOs by the metabolic glycoengineering of adipose-derived stem cells to target activated macrophages in the inflamed joints of rheumatoid arthritis.

[Haematologica] With the hypothesis that granulocyte colony-stimulating factor has different effects on different types of hematopoietic stem cells, researchers performed serum-free single-cell culture and competitive repopulation with cultured cells.