mammary cells

[Cell Death Discovery] Through investigating cellular functions including cell proliferation and stem cell features, it was demonstrated that hypoxic cancer-associated fibroblasts exosomes transferred circHIF1A into breast cancer cells, which played an important role in cancer stem cell properties sponging miR-580-5p by regulating CD44 expression.

[Biomedicine & Pharmacotherapy] A library of 17 C1-single and C1/C20-double modified salinomycin analogs was screened to identify compounds with improved activity against breast cancer stem cells.

[Cancer Research] Researchers explored whether the microbiome of the gut and mammary gland mediates the dietary effects on breast cancer. In vitro models of the normal breast epithelium showed that lipopolysaccharide disrupted tight junctions and compromised epithelial permeability.

[Oncogene] Researchers showed that cytoplasmic complexes composed of steroid receptor co-activators, PELP1 and SRC-3, modulated breast cancer stem cell expansion through upregulation of the HIF-activated metabolic target genes PFKFB3 and PFKFB4.

[Clinical Cancer Research] Old and young mouse brains, metastatic and naïve, were analyzed by flow cytometry. Immune populations were depleted using antibodies or a colony stimulating factor-1 receptor (CSF-1R) inhibitor, and brain metastasis assays were conducted.

[Molecular Cancer Research] To understand how 223RaCl2, an alpha particle emitting radiopharmaceutical, affects the growth delay of disseminated tumor cells, scientists quantified the biological changes caused by direct effects of radiation and bystander effects caused by the emitted radiations on mammary tumor cells.