A library of 17 C1-single and C1/C20-double modified salinomycin analogs was screened to identify compounds with improved activity against breast cancer stem cells.
[Biomedicine & Pharmacotherapy]
6445212 5FNTNFTC items 1 apa 0 default asc 1 163407 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-b2478680de435fc4dbe3dd86e9dc0a6e%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%225FNTNFTC%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Urbaniak%20et%20al.%22%2C%22parsedDate%22%3A%222021-09-01%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EUrbaniak%2C%20A.%2C%20Reed%2C%20M.%20R.%2C%20Fil%2C%20D.%2C%20Moorjani%2C%20A.%2C%20Heflin%2C%20S.%2C%20Antoszczak%2C%20M.%2C%20Sulik%2C%20M.%2C%20Huczy%26%23x144%3Bski%2C%20A.%2C%20Kupsik%2C%20M.%2C%20Eoff%2C%20R.%20L.%2C%20MacNicol%2C%20M.%20C.%2C%20Chambers%2C%20T.%20C.%2C%20%26amp%3B%20MacNicol%2C%20A.%20M.%20%282021%29.%20Single%20and%20double%20modified%20salinomycin%20analogs%20target%20stem-like%20cells%20in%202D%20and%203D%20breast%20cancer%20models.%20%3Ci%3EBiomedicine%20%26amp%3B%20Pharmacotherapy%3C%5C%2Fi%3E%2C%20%3Ci%3E141%3C%5C%2Fi%3E%2C%20111815.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.biopha.2021.111815%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.biopha.2021.111815%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3D5FNTNFTC%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Single%20and%20double%20modified%20salinomycin%20analogs%20target%20stem-like%20cells%20in%202D%20and%203D%20breast%20cancer%20models%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alicja%22%2C%22lastName%22%3A%22Urbaniak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Megan%20R.%22%2C%22lastName%22%3A%22Reed%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Fil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anika%22%2C%22lastName%22%3A%22Moorjani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%22%2C%22lastName%22%3A%22Heflin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Micha%5Cu0142%22%2C%22lastName%22%3A%22Antoszczak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Micha%5Cu0142%22%2C%22lastName%22%3A%22Sulik%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adam%22%2C%22lastName%22%3A%22Huczy%5Cu0144ski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michalina%22%2C%22lastName%22%3A%22Kupsik%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%20L.%22%2C%22lastName%22%3A%22Eoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melanie%20C.%22%2C%22lastName%22%3A%22MacNicol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Timothy%20C.%22%2C%22lastName%22%3A%22Chambers%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Angus%20M.%22%2C%22lastName%22%3A%22MacNicol%22%7D%5D%2C%22abstractNote%22%3A%22Breast%20cancer%20remains%20one%20of%20the%20leading%20cancers%20among%20women.%20Cancer%20stem%20cells%20%28CSCs%29%20are%20tumor-initiating%20cells%20which%20drive%20progression%2C%20metastasis%2C%20and%20reoccurrence%20of%20the%20disease.%20CSCs%20are%20resistant%20to%20conventional%20chemo-%20and%20radio-therapies%20and%20their%20ability%20to%20survive%20such%20treatment%20enables%20tumor%20reestablishment.%20Metastasis%20is%20the%20main%20cause%20of%20mortality%20in%20women%20with%20breast%20cancer%2C%20thus%20advances%20in%20treatment%20will%20depend%20on%20therapeutic%20strategies%20targeting%20CSCs.%20Salinomycin%20%28SAL%29%20is%20a%20naturally%20occurring%20polyether%20ionophore%20antibiotic%20known%20for%20its%20anticancer%20activity%20towards%20several%20types%20of%20tumor%20cells.%20In%20the%20present%20work%2C%20a%20library%20of%2017%20C1-single%20and%20C1%5C%2FC20-double%20modified%20SAL%20analogs%20was%20screened%20to%20identify%20compounds%20with%20improved%20activity%20against%20breast%20CSCs.%20Six%20single-%20and%20two%20double-modified%20analogs%20were%20more%20potent%20%28IC50%20range%20of%201.1%5Cu00a0%5Cu00b1%5Cu00a00.1%5Cu20131.4%5Cu00a0%5Cu00b1%5Cu00a00.2%5Cu00a0%5Cu00b5M%29%20toward%20the%20breast%20cancer%20cell%20line%20MDA-MB-231%20compared%20to%20SAL%20%28IC50%20of%204.9%5Cu00a0%5Cu00b1%5Cu00a01.6%5Cu00a0%5Cu00b5M%29.%20Double-modified%20compound%2017%20was%20found%20to%20be%20more%20efficacious%20than%20SAL%20against%20the%20majority%20of%20cancer%20cell%20lines%20in%20the%20NCI-60%20Human%20Tumor%20Cell%20Line%20Panel.%20Compound%2017%20was%20more%20potent%20than%20SAL%20in%20inhibiting%20cell%20migration%20and%20cell%20renewal%20properties%20of%20MDA-MB-231%20cells%2C%20as%20well%20as%20inducing%20selective%20loss%20of%20the%20CD44%2B%5C%2FCD24%5C%2Flow%20stem-cell-like%20subpopulation%20in%20both%20monolayer%20%282D%29%20and%20organoid%20%283D%29%20culture.%20The%20present%20findings%20highlight%20the%20therapeutic%20potential%20of%20SAL%20analogs%20towards%20breast%20CSCs%20and%20identify%20select%20compounds%20that%20merit%20further%20study%20and%20clinical%20development.%22%2C%22date%22%3A%22September%201%2C%202021%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.biopha.2021.111815%22%2C%22ISSN%22%3A%220753-3322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0753332221005977%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-06-14T17%3A26%3A04Z%22%7D%7D%5D%7D
Urbaniak, A., Reed, M. R., Fil, D., Moorjani, A., Heflin, S., Antoszczak, M., Sulik, M., Huczyński, A., Kupsik, M., Eoff, R. L., MacNicol, M. C., Chambers, T. C., & MacNicol, A. M. (2021). Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models. Biomedicine & Pharmacotherapy, 141, 111815. https://doi.org/10.1016/j.biopha.2021.111815 Cite