mass spectrometry

[Journal of Biological Chemistry] Investigtors established a system-wide profile of the KRAS-regulated kinase signaling network in KRAS-mutant pancreatic ductal adenocarcinoma.

[British Journal of Cancer] The mechanisms underlying metastasis of colorectal cancer (CRC) remain unclear. In human CRC specimens, a decrease in C14orf159 expression at the invasive front of the tumor and in metastasis was determined.

[Cell Death & Disease] Researchers found a potential association between deletion of smooth muscle 22α and deregulated nuclear receptors liver X receptors /retinoid X receptor signaling in mice.

[Prostate] The authors used mass spectrometry and analyzed the distribution of the site-specific glycoforms of prostate-specific membrane antigens in insect, human embryonic kidney, and prostate cancer cells, and in prostate tissue upon immunoaffinity enrichment.

[Cell Death & Disease] Scientists evaluated the function of golgi phosphoprotein 3 (GOLPH3) in non-small-cell lung cancer (NSCLC) distal metastasis. GOLPH3 was expressed at high levels in samples from patients with NSCLC and was positively associated with clinicopathologic characteristics including clinical stage classification.

[Translational Psychiatry] Utilizing iPSCs from 25 human donors, researchers generated 3D cerebral organoids, employed 16-plex isobaric sample-barcoding chemistry, and simultaneously subjected samples to comprehensive high-throughput liquid-chromatography/mass-spectrometry quantitative proteomics.