mass spectrometry

[Cancer Research] Researchers revealed a critical role for HOXC-AS3 in regulating the metabolic reprogramming of breast cancer cells under metabolic stress.

[Nature Cell Biology] Using wild-type and a trapping-deficient poly (ADP-ribose) polymerase (PARP1) mutant combined with rapid immunoprecipitation mass spectrometry of endogenous proteins and Apex2 proximity labeling, investigators delineated mass spectrometry-based interactomes of trapped and non-trapped PARP1.

[Cell Reports] Investigators showed that STK35 and PDIK1L function catalytically and redundantly in the same pathway as SCP4 to maintain acute myeloid leukemia proliferation and to support amino acid biosynthesis and transport.

[Cellular & Molecular Immunology] Scientists highlight how the use of high-resolution mass spectrometry to analyze T cell proteomes can improve our understanding of how these processes are regulated.

[Journal of Cellular and Molecular Medicine] High serum CD44 levels may help identify docetaxel-resistant patients and may thereby help optimize clinical decision-making regarding type and timing of therapy for metastatic CRPC patients patients.

[Proteome Science] Human peripheral blood mononuclear cells were stimulated with macrophage colony-stimulating factor, and obtained macrophages were transformed into foam cells by oxidized low-density lipoprotein.