mass spectrometry

[Aging Cell] Using 3xTg and APP/PS1 mouse models of Alzheimer's disease, and in vitro model of amyloid beta42 toxicity in primary neuronal cultures and SH-SY5Y neuroblastoma cells, scientists have uncovered a key role for cathepsin L in the induction of nuclear lamina damage.

[Nature Communications] Investigators reported that the neuronal ECM could be remodeled frequently through mechanisms that involved endocytosis and recycling of ECM proteins.

[Cytotherapy] The allorejection of MSCs indicates that they are not fully immune-privileged. The authors investigated the immunogenicity of human adipose-derived MSCs and identified potential immunogenic molecules.

[Oncogene] Investigators showed that endothelial-to-osteoblast (EC-to-OSB) transition led to changes in the tumor microenvironment that increased the metastatic potential of prostate cancer (PCa) cells. They found that conditioned medium from EC-OSB hybrid cells increased the migration and survival of PC3-mm2 and C4-2B4 PCa cells.

[Expert Review of Proteomics] The authors provide a concise overview of the prostate cancer metabolomics-based potential discriminating molecules in urine samples using nuclear magnetic resonance spectroscopy and mass spectrometry.

[Nature Communications] Using stable isotope labeling and mass spectrometry, research determine the in vivo turnover rates of thousands of proteins—including those of the extracellular matrix—in a set of biologically important mouse tissues.