megakaryocytes

[Thrombosis and Haemostasis] Human hematopoietic stem cells were differentiated into megakaryocytes, enabling the transfection of miR-204-5p and the recovery of subsequent platelet-like structures.

[Scientific Reports] Investigators present a high throughput strategy for identifying and isolating megakaryocytes and their progenitor cells from a heterogeneous population of bone marrow samples.

[PLoS One] The authors characterized the human hematopoietic stem cell and progenitor microenvironment. They obtained three adjacent bone marrow sections from ten healthy volunteers.

[Nature Medicine] Scientists highlight the coordinated immune response that contributes to COVID-19 pathogenesis and reveals discrete cellular components that can be targeted for therapy.

[Journal of Thrombosis and Haemostasis] iPSCs were reprogrammed from peripheral blood mononuclear cells and megakaryocytes were derived from the iPSCs in 194 healthy European American and African American subjects. mRNA was isolated and gene expression measured by RNA sequencing. Protein expression was measured in 62 of the subjects using mass spectrometry.

[Angiogenesis] Sequential waves of definitive hematopoiesis arise from yolk sac and intembryonic hemogenic endothelia through an endothelial-to-hematopoietic transition.