Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsScientists highlight the coordinated immune response that contributes to COVID-19 pathogenesis and reveals discrete cellular components that can be targeted for therapy.
[Nature Medicine]
6445218 ITK8D2FM items 1 apa 0 default asc 1 161420 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-2766c883a401e41528c50d410cfffc6f%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22ITK8D2FM%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Stephenson%20et%20al.%22%2C%22parsedDate%22%3A%222021-04-20%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EStephenson%2C%20E.%2C%20Reynolds%2C%20G.%2C%20Botting%2C%20R.%20A.%2C%20Calero-Nieto%2C%20F.%20J.%2C%20Morgan%2C%20M.%20D.%2C%20Tuong%2C%20Z.%20K.%2C%20Bach%2C%20K.%2C%20Sungnak%2C%20W.%2C%20Worlock%2C%20K.%20B.%2C%20Yoshida%2C%20M.%2C%20Kumasaka%2C%20N.%2C%20Kania%2C%20K.%2C%20Engelbert%2C%20J.%2C%20Olabi%2C%20B.%2C%20Spegarova%2C%20J.%20S.%2C%20Wilson%2C%20N.%20K.%2C%20Mende%2C%20N.%2C%20Jardine%2C%20L.%2C%20Gardner%2C%20L.%20C.%20S.%2C%20%26%23x2026%3B%20Haniffa%2C%20M.%20%282021%29.%20Single-cell%20multi-omics%20analysis%20of%20the%20immune%20response%20in%20COVID-19.%20%3Ci%3ENature%20Medicine%3C%5C%2Fi%3E%2C%201%26%23x2013%3B13.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41591-021-01329-2%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41591-021-01329-2%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DITK8D2FM%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Single-cell%20multi-omics%20analysis%20of%20the%20immune%20response%20in%20COVID-19%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emily%22%2C%22lastName%22%3A%22Stephenson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gary%22%2C%22lastName%22%3A%22Reynolds%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rachel%20A.%22%2C%22lastName%22%3A%22Botting%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fernando%20J.%22%2C%22lastName%22%3A%22Calero-Nieto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20D.%22%2C%22lastName%22%3A%22Morgan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zewen%20Kelvin%22%2C%22lastName%22%3A%22Tuong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karsten%22%2C%22lastName%22%3A%22Bach%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Waradon%22%2C%22lastName%22%3A%22Sungnak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kaylee%20B.%22%2C%22lastName%22%3A%22Worlock%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Masahiro%22%2C%22lastName%22%3A%22Yoshida%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Natsuhiko%22%2C%22lastName%22%3A%22Kumasaka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katarzyna%22%2C%22lastName%22%3A%22Kania%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Justin%22%2C%22lastName%22%3A%22Engelbert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bayanne%22%2C%22lastName%22%3A%22Olabi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jarmila%20Stremenova%22%2C%22lastName%22%3A%22Spegarova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicola%20K.%22%2C%22lastName%22%3A%22Wilson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Mende%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Jardine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Louis%20C.%20S.%22%2C%22lastName%22%3A%22Gardner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Issac%22%2C%22lastName%22%3A%22Goh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dave%22%2C%22lastName%22%3A%22Horsfall%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jim%22%2C%22lastName%22%3A%22McGrath%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simone%22%2C%22lastName%22%3A%22Webb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20W.%22%2C%22lastName%22%3A%22Mather%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rik%20G.%20H.%22%2C%22lastName%22%3A%22Lindeboom%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emma%22%2C%22lastName%22%3A%22Dann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ni%22%2C%22lastName%22%3A%22Huang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Krzysztof%22%2C%22lastName%22%3A%22Polanski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elena%22%2C%22lastName%22%3A%22Prigmore%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Gothe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Scott%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rebecca%20P.%22%2C%22lastName%22%3A%22Payne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kenneth%20F.%22%2C%22lastName%22%3A%22Baker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aidan%20T.%22%2C%22lastName%22%3A%22Hanrath%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ina%20C.%20D.%22%2C%22lastName%22%3A%22Schim%20van%20der%20Loeff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%20S.%22%2C%22lastName%22%3A%22Barr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amada%22%2C%22lastName%22%3A%22Sanchez-Gonzalez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Bergamaschi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Federica%22%2C%22lastName%22%3A%22Mescia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Josephine%20L.%22%2C%22lastName%22%3A%22Barnes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eliz%22%2C%22lastName%22%3A%22Kilich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Angus%22%2C%22lastName%22%3A%22de%20Wilton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anita%22%2C%22lastName%22%3A%22Saigal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aarash%22%2C%22lastName%22%3A%22Saleh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sam%20M.%22%2C%22lastName%22%3A%22Janes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claire%20M.%22%2C%22lastName%22%3A%22Smith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nusayhah%22%2C%22lastName%22%3A%22Gopee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Wilson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%22%2C%22lastName%22%3A%22Coupland%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%20M.%22%2C%22lastName%22%3A%22Coxhead%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vladimir%20Yu%22%2C%22lastName%22%3A%22Kiselev%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stijn%22%2C%22lastName%22%3A%22van%20Dongen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jaume%22%2C%22lastName%22%3A%22Bacardit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hamish%20W.%22%2C%22lastName%22%3A%22King%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anthony%20J.%22%2C%22lastName%22%3A%22Rostron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%20John%22%2C%22lastName%22%3A%22Simpson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Hambleton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elisa%22%2C%22lastName%22%3A%22Laurenti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%20A.%22%2C%22lastName%22%3A%22Lyons%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kerstin%20B.%22%2C%22lastName%22%3A%22Meyer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marko%20Z.%22%2C%22lastName%22%3A%22Nikoli%5Cu0107%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%20J.%20A.%22%2C%22lastName%22%3A%22Duncan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kenneth%20G.%20C.%22%2C%22lastName%22%3A%22Smith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%20A.%22%2C%22lastName%22%3A%22Teichmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Menna%20R.%22%2C%22lastName%22%3A%22Clatworthy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20C.%22%2C%22lastName%22%3A%22Marioni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Berthold%22%2C%22lastName%22%3A%22G%5Cu00f6ttgens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Muzlifah%22%2C%22lastName%22%3A%22Haniffa%22%7D%5D%2C%22abstractNote%22%3A%22Analysis%20of%20human%20blood%20immune%20cells%20provides%20insights%20into%20the%20coordinated%20response%20to%20viral%20infections%20such%20as%20severe%20acute%20respiratory%20syndrome%20coronavirus%202%2C%20which%20causes%20coronavirus%20disease%202019%20%28COVID-19%29.%20We%20performed%20single-cell%20transcriptome%2C%20surface%20proteome%20and%20T%20and%20B%20lymphocyte%20antigen%20receptor%20analyses%20of%20over%20780%2C000%20peripheral%20blood%20mononuclear%20cells%20from%20a%20cross-sectional%20cohort%20of%20130%20patients%20with%20varying%20severities%20of%20COVID-19.%20We%20identified%20expansion%20of%20nonclassical%20monocytes%20expressing%20complement%20transcripts%20%28CD16%2BC1QA%5C%2FB%5C%2FC%2B%29%20that%20sequester%20platelets%20and%20were%20predicted%20to%20replenish%20the%20alveolar%20macrophage%20pool%20in%20COVID-19.%20Early%2C%20uncommitted%20CD34%2B%20hematopoietic%20stem%5C%2Fprogenitor%20cells%20were%20primed%20toward%20megakaryopoiesis%2C%20accompanied%20by%20expanded%20megakaryocyte-committed%20progenitors%20and%20increased%20platelet%20activation.%20Clonally%20expanded%20CD8%2B%20T%20cells%20and%20an%20increased%20ratio%20of%20CD8%2B%20effector%20T%20cells%20to%20effector%20memory%20T%20cells%20characterized%20severe%20disease%2C%20while%20circulating%20follicular%20helper%20T%20cells%20accompanied%20mild%20disease.%20We%20observed%20a%20relative%20loss%20of%20IgA2%20in%20symptomatic%20disease%20despite%20an%20overall%20expansion%20of%20plasmablasts%20and%20plasma%20cells.%20Our%20study%20highlights%20the%20coordinated%20immune%20response%20that%20contributes%20to%20COVID-19%20pathogenesis%20and%20reveals%20discrete%20cellular%20components%20that%20can%20be%20targeted%20for%20therapy.%22%2C%22date%22%3A%222021-04-20%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41591-021-01329-2%22%2C%22ISSN%22%3A%221546-170X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41591-021-01329-2%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-04-21T18%3A44%3A56Z%22%7D%7D%5D%7D
Stephenson, E., Reynolds, G., Botting, R. A., Calero-Nieto, F. J., Morgan, M. D., Tuong, Z. K., Bach, K., Sungnak, W., Worlock, K. B., Yoshida, M., Kumasaka, N., Kania, K., Engelbert, J., Olabi, B., Spegarova, J. S., Wilson, N. K., Mende, N., Jardine, L., Gardner, L. C. S., … Haniffa, M. (2021). Single-cell multi-omics analysis of the immune response in COVID-19. Nature Medicine, 1–13. https://doi.org/10.1038/s41591-021-01329-2 Cite
