melanoma

[Journal of the American Chemical Society] Investigators established a robust synthesis method for faceted nanoceria with primary particle diameters of 5–6 nm. The nanoceria were not cytotoxic to a human melanoma cell line at doses up to 400 μg/mL and were dose-dependently internalized by the cells.

[Environmental Toxicology] Vemurafenib-resistant A375.S2 cells were established, and the functional mechanism of the epidermal growth factor receptor (EGFR), serine–threonine kinase, and the extracellular signal-regulated kinase signaling induced by curcumin was investigated in A375.S2/VR cells in vitro.

[Oncoimmunology] The authors investigated the efficacy of CD29- and CD44-targeted NIR-PIT (CD29-PIT and CD44-PIT, respectively) in the B16 melanoma model, which was highly pigmented.

[Translational Oncology] Investigators suggested that stiffer substrate enhanced melanoma development by upregulating SNF5 expression, and SNF5 was a key mediator of stiffer matrix-induced immune evasion of melanoma cancer cells.

[Dermatology and Therapy] Investigators summarize the current cSCC literature with a focus on how differing clinical assessments within each of the five selected risk factors (perineural invasion, differentiation, depth of invasion, size, and location) can influence the evaluation of patient outcomes.

[Frontiers in Immunology] Scientists examined the effect of selectively blocking the function of sCTLA-4 on in vitro immune responses from volunteer healthy or melanoma patient PBMC samples.