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melanoma

Biosafety and Differentially Expressed Genes Analysis of Melanoma Cells Treated with Cold Atmospheric Plasma

[Journal of Biophotonics] Researchers evaluated cell viability, apoptosis rate, and reactive species injection efficiency of melanoma cells and human keratinocyte cells treated with cold atmospheric plasma and analyzed its biological safety.

Biomimetic Immunosuppressive Exosomes that Inhibit Cytokine Storms Contribute to the Alleviation of Sepsis

[Advanced Materials] Investigators observed that experimental tumor-bearing animals had high survival rates after sepsis induction, suggesting that tumors may have suppressed sepsis-associated immune overactivation, thereby alleviating sepsis.

Exploiting LRRC15 as a Novel Therapeutic Target in Cancer

[Cancer Research] The authors focus on the role of leucine-rich repeat-containing protein (LRRC15) in cancer, including clinical trials involving LRRC15-targeted therapies, such as the ABBV-085 ADC for patients with LRRC15-positive tumors.

Human Epigenetic and Transcriptional T Cell Differentiation Atlas for Identifying Functional T Cell-Specific Enhancers

[Immunity] Researchers generated an epigenetic and transcriptional atlas of T cell differentiation from healthy humans that included exhausted CD8 T cells and applied this resource in three ways.

Tumor-B Cell Interactions Promote Isotype Switching to an Immunosuppressive IgG4 Antibody Response through Upregulation of IL-10 in Triple Negative Breast Cancers

[Journal of Translational Medicine] Investigators performed co-culture assays to examine expression of Th2 cytokines by triple negative breast cancer cells with and without the presence of B cells.

TRAF6-Overexpressing Dendritic Cells Loaded with MUC1 Peptide Enhance Anti-Tumor Activity in B16-MUC1 Melanoma-Bearing Mice

[International Immunopharmacology] Tumor necrosis factor receptor-associated factor 6 (TRAF6)-overexpressing dendritic cells had increased expression of costimulatory molecules, major histocompatibility complex molecules and IL-12 expression.

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