mesenchymal cells

[Developmental Cell] The authors describe a cellular contractile mechanism employed by fibroblasts and mesenchymal cancer cells to migrate in 3D collagen gels.

[International Journal of Oral Science] The authors showed that ubiquitin-specific protease 34 (USP34) plays a pivotal role in root formation. Deletion of Usp34 in dental mesenchymal cells led to short root anomaly, characterized by truncated roots and thin root dentin.

[Nature Protocols] Scientists describe a detailed protocol for establishing tubuloid cultures from tissue and urine, as well as for generating and characterizing tubuloid cell–derived 3D tubular structures in a perfused microfluidic multi-chip platform.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers specifically depleted H3K36me2 or H3K36me3 in mesenchymal cells, using CRISPR-Cas9 to separately knock out the corresponding methyltransferases NSD1/2 or SETD2.

[Cell Reports] Scientists performed lineage tracing studies by using various genetic models and find that cardiac mesenchymal cells contribute to cardiac adipocytes in postnatal development and adult homeostasis.

[Cell Death & Disease] The authors suggest that micro-heterogeneity takes part in the fate decision of a mesenchymal cell population involved in the pathogenesis of a genetic disease.