mesenchymal cells

[American Journal of Physiology-Gastrointestinal and Liver Physiology] Scientists used a novel co-culture system with E14.5 intestinal epithelial organoids to examine the microenvironmental cues that regulate the embryonic stem/progenitor population, focusing on the role of Notch pathway factor, Delta-Like Protein 1.

[Scientific Reports] Epithelial cell rests of malassez was cultured in ESC medium with 1 µM of 5-Azacytidine (5Aza), or 2 mM ofvalproic acid (Vpa), or a combination of 5Aza and Vpa. The cells stimulated with both 5Aza and Vpa were named as progenitor-dedifferentiated into stem-like cells.

[Scientific Reports] Researchers examined the roles of 5-Azacytidine and valproic acid in the dedifferentiation of epithelial cell rests of Malassez into stem-like cells. Additionally, the ability of stem-like cells to differentiate into mesenchymal cells was evaluated.

[Cancer Letters] Investigators evaluated two properties of a novel source of MSCs- first trimester human umbilical cord perivascular cells- that may render them a promising candidate for chemotherapeutic gonadal injury prevention.

[Cancer Gene Therapy] To identify key drivers of metastasis, scientists studied human CCH-OS-D osteocarcinoma cells within a previously described rat acellular lung model that preserved the native lung architecture, extracellular matrix, and capillary network.

[Cell Reports] Scientists highlighted the dynamics of mesenchymal cells in the airway niche and implications for chronic airway-injury-associated diseases.