mesenchymal stem cells

[Stem Cells International] The authors summarize current knowledge on how stem cell-derived nanovesicles regulate immunity, fibroblast activity, angiogenesis, and scar formation in the wound healing process.

[Journal of Inflammation Research] Investigators recapitulate the molecular basis of bone marrow (BM)MSC-assisted biological processes and summarizes the possible mechanisms related to the interaction between BMMSCs and microglia.

[Stem Cells Translational Medicine] A Phase Ib study was conducted to evaluate the safety and immunoregulatory mechanism of action of MSCs using a novel ex vivo product to preserve cell activity in patients with severe acute kidney injury.

[Tissue Engineering and Regenerative Medicine] MSC aggregation into spheroids was optimized in vitro based on cellular viability, spheroid size, and trophic factor secretion. The regenerative potential of the optimized MSC spheroid therapy was then investigated in a murine model of volumetric muscle loss injury.

[Scientific Reports] To determine how a prolonged treatment could impair their functional characteristics, scientists exposed human MSCs to increasing morphine concentrations respectively for nine and eighteen days, evaluating in particular the fibrogenic potential exerted by the long-term exposition.

[Pediatric Research] The authors examined the effects of amniotic fluid and mesenchymal stem cells on the prevention of intestinal injury during experimental necrotizing enterocolitis.