Co-Delivery of Fibrin-Laminin Hydrogel with Mesenchymal Stem Cell Spheroids Supports Skeletal Muscle Regeneration Following Trauma

MSC aggregation into spheroids was optimized in vitro based on cellular viability, spheroid size, and trophic factor secretion. The regenerative potential of the optimized MSC spheroid therapy was then investigated in a murine model of volumetric muscle loss injury.