mesenchymal stem cells

[Cell and Tissue Research] The authors focus on the latest research and applications of human-derived umbilical cord MSC in the treatment and management of T2DM, exploring and systematizing the key effects of both umbilical cord MSC and its factor-rich secretome accordingly with the major complications associated to T2DM.

[Nature Biomedical Engineering] The authors showed that MSCs singly coated with a soft conformal gel presenting defined chemomechanical cues promoted matrix remodeling by secreting soluble interstitial collagenases in response to the presence of tumour necrosis factor alpha.

[Cell Death & Disease] Researchers showed that conditional knockout of the demethylase Alkbh5 in bone marrow MSCs strengthened bone mass in mice.

[ACS Applied Materials & Interfaces] PMNT was confirmed to promote human umbilical cord-derived MSC proliferation in a serum-free medium by driving cell cycles and up-regulating gene expression in the pathways of biosynthesis and the metabolism.

[Stem Cells and Development] Investigators aimed to fabricate a Matrigel scaffold loaded with human umbilical cord-derived MSCs and explore its potential to restore ovarian function and repair ovarian structures in vitro and in vivo.

[PLOS One] Researchers compared the ability of regulatory T cells (Treg) + mesenchymal stromal cells (MSC) combination therapy, as well as MSC and Treg monotherapies, to improve blood brain barrier permeability in vivo and suppress inflammation in vitro.