monocytes

[International Immunopharmacology] Scientists examined the effect of interferon regulatory factor 4 (IRF-4) deficiency on inflammation and kidney fibrosis in an acute kidney injury-chronic kidney disease transition model induced by folic acid injury.

[Aging-Us] The authors found that conditioned medium harvested from WI-38 lung fibroblasts and H1299 lung adenocarcinoma cells exposed to 0.1Gy to 1Gy could enhance the migration and invasion of unirradiated H1299 cells in both 2D and 3D culturing circumstances.

[Cell Stem Cell] The authors demonstrated that osteoblastic cells in the bone marrow niche elaborated extracellular vesicles (EV) that were taken up by hematopoietic progenitor cells in vivo, and that upregulating EV transfer improved hematopoietic recovery from genotoxic injury and survival from fungal sepsis.

[Cell Reports] Scientists highlighted RUNX1 and CEBPA transcription factor swapping as a feature of leukemia cell differentiation and revealed that FOXC1 prevented this by stabilizing enhancer binding of a RUNX1/HDAC1/TLE3 transcription repressor complex to oncogenic effect.

[Cell Reports] Restoration of the gut bile acids pool attenuated severity of experimental autoimmune uveitis in association with inhibition of nuclear factor κB related pro-inflammatory cytokines in dendritic cells.

[Frontiers in Immunology] Analysis of fresh tumor samples from clear cell renal cell carcinoma patients unraveled the presence of a high frequency of tumor-infiltrating PD-L1+ natural killer (NK cells), suggesting that these NK cells might exhibit immunoregulatory functions.