Enhancer Recruitment of Transcription Repressors RUNX1 and TLE3 by Mis-Expressed FOXC1 Blocks Differentiation in Acute Myeloid Leukemia

Scientists highlighted RUNX1 and CEBPA transcription factor swapping as a feature of leukemia cell differentiation and revealed that FOXC1 prevented this by stabilizing enhancer binding of a RUNX1/HDAC1/TLE3 transcription repressor complex to oncogenic effect.