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monocytes

Engineered Delivery of Dental Stem Cell-Derived Extracellular Vesicles for Periodontal Tissue Regeneration

[Advanced Healthcare Materials] Investigators developed a delivery platform for small extracellular vesicles derived from gingival MSCs to treat periodontitis.

CCL2-Mediated Monocytes Regulate Immune Checkpoint Blockade Resistance in Pancreatic Cancer

[International Immunopharmacology] Scientists found that C-C motif chemokine ligand 2 (CCL2) recruits monocytes to and decrease CD8+ T cell infiltration in pancreatic tumors.

CCL2-Mediated Monocytes Regulate Immune Checkpoint Blockade Resistance in Pancreatic Cancer

[International Immunopharmacology] Scientists found that C-C motif chemokine ligand 2 (CCL2) recruits monocytes to and decrease CD8+ T cell infiltration in pancreatic tumors.

Increased Visceral Fat Distribution and Body Composition Impact Cytokine Release Syndrome Onset and Severity after CD19 CAR-T in Advanced B Cell Malignancies

[Haematologica] Researchers studied the influence of anthropometric and body composition measurements on CAR-T-related immunotoxicity in 64 patients receiving CD19-directed CAR-T for relapsed/refractory B cell malignancies.

Single-Cell Isoform Analysis in Human Immune Cells

[Genome Biology] The authors used R2C2 to sequence and demultiplex 12 million full-length cDNA molecules generated by the 10X Genomics platform from ~3000 peripheral blood mononuclear cells.

Glutaredoxin 1 Controls Monocyte Reprogramming during Nutrient Stress and Protects Mice against Obesity and Atherosclerosis in a Sex-Specific Manner

[Nature Communications] The authors reported that in chow-fed, reproductively senescent female mice but not in age-matched male mice, deficiency in the thiol transferase glutaredoxin 1 promoted dysregulated macrophage phenotypes as well as rapid weight gain and atherogenesis.

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