myeloid cells

[Cancer Research] In a syngeneic model that reflected the mutational landscape of castrate-resistant prostate cancer, macrophage depletion resulted in a reduced transcriptional signature for steroid and bile acid synthesis, indicating potential perturbation of cholesterol metabolism.

[Cell Death Discovery] C5aR1-positive neutrophil-secreted IL1β and TNFα cooperatively activate ERK1/2 signaling, which phosphorylated WTAP at serine341 and thereby stabilized WTAP protein. The stabilization of WTAP further promotes RNA m6A methylation of ENO1, impacting the glycolytic activity of breast cancer cells.

[Scientific Reports] Scientists presented an integrative analysis of clinical data, cytokines, serum metabolomics in rheumatoid arthritis patients and mechanistic studies on adenosine deaminase-mediated effects on in vitro cell culture models.

[Stem Cell Reports] Investigators reported a new brain region-specific, microglia-containing organoid model by co-culturing human PSC-derived primitive neural progenitor cells and primitive macrophage progenitors.

[Journal of Experimental Medicine] Scientists review the interactions between immune cells and astrocytes and their roles in health and neurological diseases, with a special focus on multiple sclerosis.

[Circulation Research] The authors tested whether silencing netrin-1 in advanced atherosclerosis could resolve arterial inflammation and regress plaques.